Publications

62. Krantz BA. (2026) “Antagonistic Pleiotropy at the HCAR1 Locus Reveals a Genetic Basis for Solid Tumor Resistance in Schizophrenia.” medRxiv

61. Taylor JE, Sharma P, Krantz BA. (2026) “Single-Molecule Proteomics via a Dynamic Translocase and Physics-Informed Machine Learning.” bioRxiv

60. Taylor JE, Sharma P, Krantz BA. (2026) “Beyond the Static Caliper: Dynamical Translocases and the Mathematical Imperative for Single-Molecule Proteomics.” bioRxiv

59. Krantz BA. (2026) “Shared Genomic Architecture Between Schizophrenia and Multiple Sclerosis Identifies an Un-Drugged HCAR1 Neuroimmune Checkpoint.” bioRxiv

58. Krantz BA. (2026) “State-Dependent Transcriptomic Collapse of the Brain's Lactate and Ketone Thermodynamic Sensors in Schizophrenia.” bioRxiv

57. Krantz BA. (2026) “Metabolic Gating and the Evolution of Human Cognitive Plasticity: A Comparative Genomic Analysis.” bioRxiv

56. Colby JM, Krantz BA. (2026) “Rational Engineering of the Anthrax Toxin Nanopore Interface for Orthogonal Peptide Classification.” ACS Omega 11: 34099.

55. Colby JM, Krantz BA. (2026) “A Dynamical Anthrax Toxin Nanopore Biosensor for High-Fidelity Single-Peptide Classification.” PLoS Comput. Biol. 22: e1014019.

54. Colby JM, Krantz BA. (2026) “Peptide properties predict multi-state translocation kinetics via protective antigen nanopores.” Biophys. J. 125: 1095.

53. Colby JM, Krantz BA. (2026) “Dynamic Gating by ϕ-clamp Loop Controls Peptide Translocation Through the Anthrax Toxin Nanopore.” Biophys. J. 125: 758.

52. Krantz BA. (2025) "Deep learning-based classification of peptide analytes from single-channel nanopore translocation events." PLoS One. 20: e0324777.

51. Krantz BA. (2024) "Anthrax Toxin: Model System for Studying Protein Translocation." J. Mol. Biol. 436: 168521.

50. Zhou K, Liu S, Hardenbrook NJ, Cui Y, Krantz BA, Zhou ZH. (2020) "Atomic Structures of Anthrax Prechannel Bound with Full-Length Lethal and Edema Factors." Structure. 28: 879.

Highlight Preview: “Cryo-EM Uncovers Atomic Details for Loading Cell-Killing Enzymes to the Anthrax Toxin Pretranslocation Complex” by Xiaodan Ni and Jiansen Jiang. Structure. 28: 871.

49. Hardenbrook NJ, Liu S, Zhou K, Ghosal K, Zhou ZH, Krantz BA. (2020) "Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors." Nat. Commun. 11: 840.

48. Krantz BA. (2017) "Reply to Yamini and Nestorovich: Alternate clamped states of the anthrax toxin protective antigen channel" Proc. Natl Acad. Sci. 114: E2547.

47. Ghosal K, Colby JM, Das D, Joy ST, Arora PS, Krantz BA. (2017) "Dynamic Phenylalanine Clamp Interactions Define Single-Channel Polypeptide Translocation through the Anthrax Toxin Protective Antigen Channel." J. Mol. Biol. 429: 900.

46. Das D, Krantz BA. (2017) "Secondary Structure Preferences of the Anthrax Toxin Protective Antigen Translocase." J. Mol. Biol. 429: 753.

45. Das D, Krantz BA. (2016) "Peptide- and proton-driven allosteric clamps catalyze anthrax toxin translocation across membranes." Proc. Natl Acad. Sci. 113: 9611.

44. Jorgensen I, Zhang Y, Krantz BA, Miao EA. (2016) "Pyroptosis triggers pore-induced intracellular traps (PITs) that capture bacteria and lead to their clearance by efferocytosis." J. Exp. Med. 213: 2113.

43. Krantz BA. (2016) "Anthrax lethal toxin co-complexes are stabilized by contacts between adjacent lethal factors." J. Gen. Physiol. 148: 273.

42. Biondi E, Lane JD, Das D, Dasgupta S, Piccirilli JA, Hoshika S, Bradley KM, Krantz BA, Benner SA. (2016) "Laboratory evolution of artificially expanded DNA gives redesignable aptamers that target the toxic form of anthrax protective antigen." Nucleic Acids Res. 44: 9565.

41. Colby JM, Krantz BA. (2015) "Peptide Probes Reveal a Hydrophobic Steric Ratchet in the Anthrax Toxin Protective Antigen Translocase." J. Mol. Biol. 427: 3598.

40. Brown MJ, Thoren KL, Krantz BA. (2015) "Role of the α Clamp in the Protein Translocation Mechanism of Anthrax Toxin." J. Mol. Biol. 427: 3340.

Ch. Krantz BA. (2015) "Anthrax Toxin Protective Antigen Forms an Unusual Channel That Unfolds and Translocates Proteins Across Membranes" in Electrophysiology of Unconventional Channels and Pores edited by Delcour AH. Springer International Publishing, Switzerland.

39. Abrami L, Brandi L, Moayeri M, Brown MJ, Krantz BA, Leppla SH, van der Goot FG. (2013) "Hijacking multivesicular bodies enables long-term and exosome-mediated long-distance action of anthrax toxin." Cell Rep. 5: 986.

38. Wynia Smith SL, Brown MJ, Chirichella G, Krantz BA. (2012) "Electrostatic Ratchet In The Protective Antigen Channel Promotes Anthrax Toxin Translocation." J. Biol. Chem. 287: 43753.

37. Kintzer AF, Tang II, Schawel AK, Brown MJ, Krantz BA. (2012) "Anthrax toxin protective antigen integrates poly-γ-d-glutamate and pH signals to sense the optimal environment for channel formation." Proc. Natl Acad. Sci. 109: 18378.

36. von Moltke J, Trinidad NJ, Moayeri M, Kintzer AF, Wang SB, van Rooijen N, Brown CR, Krantz BA, Leppla SH, Gronert K, Vance RE. (2012) "Rapid induction of inflammatory lipid mediators by the inflammasome in vivo." Nature. 490: 107.

35. Feld GK, Brown MJ, Krantz BA. (2012) "Ratcheting up protein translocation with anthrax toxin." Protein Sci. 21: 606.

Highlights: In this Issue. "Ratcheting up protein translocation with anthrax toxin" Protein Sci. 21.

34. Feld GK, Kintzer AF, Tang II, Thoren KL, Krantz BA. (2012) "Domain flexibility modulates the heterogeneous assembly mechanism of anthrax protective antigen." J. Mol. Biol. 415: 159.

33. Sterling HJ, Kintzer AF, Feld GK, Cassou CA, Krantz BA, Williams ER. (2012) "Supercharging Protein Complexes from Aqueous Solution Disrupts their Native Conformations." J. Am. Soc. Mass Spectrom. 23: 191.

32. Sterling HJ, Cassou CA, Trnka MJ, Burlingame AL, Krantz BA, Williams ER. (2011) "The role of conformational flexibility on protein supercharging in native electrospray ionization." Phys. Chem. Chem. Phys. 13: 18288.

31. Brown MJ, Thoren KL, Krantz BA. (2011) "Charge requirements for proton gradient-driven translocation of anthrax toxin." J. Biol. Chem. 286: 23189.

30. Thoren KL & Krantz BA. (2011) "The unfolding story of anthrax toxin translocation." Mol. Micro. 80: 588.

29. Feld GK, Thoren KL, Kintzer AF, Sterling HJ, Tang II, Greenberg SG, Williams ER, Krantz BA. (2010) "Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers." Nature Struct. Mol. Biol. 17: 1383.

Spotlight: "The Tale of Anthrax Unfolds" by Eva J. Gordon ACS Chem. Biol. 5: 1093.

28. Kintzer AF, Sterling HJ, Tang II, Williams ER, Krantz BA. (2010) "Anthrax toxin receptor drives protective antigen oligomerization and stabilizes the heptameric and octameric oligomer by a similar mechanism." PLoS ONE 5: e13888.

27. Sterling HJ, Daly MP, Feld GK, Thoren KL, Kintzer AF, Krantz BA, Williams ER. (2010) "Effects of supercharging reagents on noncovalent complex structure in electrospray ionization from aqueous solutions." J. Am. Soc. Mass Spectrom. 21: 1762.

26. Kintzer AF, Sterling HJ, Tang II, Abdul-Gader A, Miles AJ, Wallace BA, Williams ER, Krantz BA. (2010) "Role of the protective antigen octamer in the molecular mechanism of anthrax lethal toxin stabilization in plasma." J. Mol. Biol. 399: 741.

25. Thoren KL, Worden EJ, Yassif JM, Krantz BA. (2009) "Lethal factor unfolding is the most force-dependent step of anthrax toxin translocation." Proc. Natl Acad. Sci. 106: 21555.

24. Kintzer AF, Thoren KL, Sterling HJ, Dong KC, Feld GK, Tang II, Zhang TT, Williams ER, Berger JM, Krantz BA. (2009) "The protective antigen component of anthrax toxin forms functional octameric complexes." J. Mol. Biol. 392: 614.

23. Krantz B. (2009) "Bryan Krantz: From folding to unfolding proteins. Interview by Liz Savage." J. Cell Biol. 184: 618.

22. Pandit AD, Krantz BA, Dothager RS, Sosnick TR. (2007) "Characterizing protein folding transition States using Ψ-analysis." Methods Mol. Biol. 350: 83.

21. Sosnick TR, Krantz BA, Dothager RS, Baxa M. (2006) "Characterizing the protein folding transition state using Ψ analysis." Chem. Rev. 106: 1862.

20. Christensen KA, Krantz BA, Collier RJ. (2006) "Assembly and disassembly kinetics of anthrax toxin complexes." Biochemistry. 45: 2380.

19. Krantz BA, Finkelstein A, Collier RJ. (2006) "Protein translocation through the anthrax toxin transmembrane pore is driven by a proton gradient." J. Mol. Biol. 355: 968.

18. Wolfe JT, Krantz BA, Rainey GJA, Young JAT, Collier RJ. (2005) "Whole-cell voltage clamp measurements of anthrax protective antigen pores." J. Biol. Chem. 280: 39417.

17. Krantz BA, Melnyk RA, Zhang S, Juris SJ, Lacy DB, Wu Z, Finkelstein A, Collier RJ. (2005) "A phenylalanine clamp catalyzes protein translocation through the anthrax toxin pore." Science. 309: 777.

Enhanced Perspectives article: "Translocation of Anthrax Toxin: Lord of the Rings" by Gunnar von Heijne in Science 309: 709.
Press highlight: "Toxin Channeling" by Celia Henry in Chemical & Engineering News 83: 13.

16. Christensen KA, Krantz BA, Melnyk RA, Collier RJ. (2004) "Interaction of the 20 kDa and 63 kDa fragments of anthrax protective antigen: kinetics and thermodynamics." Biochemistry 44: 1047.

15. Sosnick TR, Dothager RS, Krantz BA. (2004) "Differences in the folding transition state of ubiquitin indicated by Φ- and Ψ-analyses." Proc. Natl Acad. Sci. 101: 17377.

Commentary by Alan Fersht in Proc. Natl Acad. Sci. 101: 17327. [Journal]

14. Krantz BA, Trivedi AD, Cunningham K, Christensen KA, Collier RJ. (2004) "Anthrax toxin's lethal and edema factors unfold under acidic pH conditions." J. Mol. Biol. 344: 739.

13. Pimental RA, Christensen KA, Krantz BA, Collier RJ. (2004) "Anthrax toxin complexes: heptameric protective antigen can bind lethal factor and edema factor simultaneously." Biochem. Biophys. Res. Commun. 322: 258.

12. Wigelsworth DJ, Krantz BA, Christensen KA, Lacy DB, Juris SJ, Collier RJ. (2004) "Binding stoichiometry and kinetics of the interaction of a human anthrax toxin receptor, CMG2, with protective antigen." J. Biol. Chem. 279: 23349.

11. Jacob J, Krantz B, Dothager RS, Thiyagarajan P, Sosnick TR. (2004) "Early collapse is not an obligate step in protein folding." J. Mol. Biol. 338: 369.

10. Krantz BA, Dothager R, Sosnick TR. (2004) "Discerning the structure and energy of multiple transition states in protein folding using Ψ-analysis." J. Mol. Biol. 337: 463.

Erratum (2005): J. Mol. Biol. 347: 1103.

Diss. Krantz, BA. (2002) Protein folding: new methods unveil rate-limiting structures. Ph.D. diss. University of Chicago.

9. Krantz BA, Mayne L, Rumbley J, Englander SW, Sosnick TR. (2002) "Fast and slow intermediate accumulation and the initial barrier mechanism in protein folding." J. Mol. Biol. 324: 359.

8. Krantz BA, Srivastava AK, Nauli S, Baker D, Sauer RT, Sosnick TR. (2002) "Understanding protein hydrogen bond network formation with kinetic D/H amide isotope effects." Nature Struct. Biol. 9: 458.

7. Shi Z, Krantz BA, Kallenbach N, Sosnick TR. (2002) "Contribution of hydrogen bonding to protein stability estimated from isotope effects." Biochemistry. 41: 2120.

6. Krantz BA, Sosnick TR. (2001) "Engineered metal binding sites map the heterogeneous folding landscape of a coiled coil." Nature Struct. Biol. 8: 1042.

5. Yin L, Krantz B, Russell NS, Deshpande S, Wilkinson KD. (2000) "Nonhydrolyzable diubiquitin analogues are inhibitors of ubiquitin conjugation and deconjugation." Biochemistry. 39: 10001.

4. Krantz BA, Sosnick TR. (2000) "Distinguishing between two-state and three-state models for ubiquitin folding." Biochemistry. 39: 11696.

3. Krantz BA, Moran LB, Kentsis A, Sosnick TR. (2000) "D/H amide kinetic isotope effects reveal when hydrogen bonds form during protein folding." Nature Struct. Biol. 7: 62.

2. Larsen CN, Krantz BA, Wilkinson KD. (1998) "Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases." Biochemistry. 37: 3358.

1. Amerik AYu, Swaminathan S, Krantz BA, Wilkinson KD, Hochstrasser M. (1997) "In vivo disassembly of free polyubiquitin chains by yeast Ubp14 modulates rates of protein degradation by the proteasome." EMBO J. 16: 4826.